Dr. Zhi Dong Zhou is graduated as a medical doctor in 1991 and had 5 years of postgraduate clinical training in internal medicine in China. Subsequently he acquired my Ph.D from Chinese Academy of Science, Shanghai Branch and started me research career in Singapore on dopamine (DA) neuron degeneration in Parkinson's disease (PD). Later he joined the National Neuroscience Institute (NNI) as a member of the Singapore National PD Translational Bench to Bedside team and continue to work on DA neuron degeneration in PD. Currently, he is an Associate Clinician Scientist in charge of the Translational Therapeutics Laboratory of NNI and an Assistant Professor at Duke-NUS, NBD as well as a PI of NMRC and SHF grants.

Research Interest: Dr. Zhi Dong Zhou’s interests lie in identification and verification of novel key molecular targets, signaling pathways or neuro-protective agents relevant to pathogenesis and therapy of debilitating human neurodegenerative diseases, including PD, Alzheimer’s disease (AD) and multiple sclerosis.

Publications:

1). Zhi Dong Zhou & Eng King Tan. Dopamine (DA) toxicity in pathogenesis and therapy of Parkinson’s disease (PD). J Clin Bioanal Chem 2017 Volume 1 Issue 1, in press.
2). Zhi Dong Zhou & Eng King Tan. Iron Regulatory Protein (IRP)-Iron Responsive Element (IRE) Signaling Pathway in Human Neurodegenerative Diseases. Molecular Neurodegeneration, in press
3). Zhong Can Zhen., ..Zhi Dong Zhou, et al. LRRK2 Interacts with ATM and Regulates Mdm2-p53 Cell Proliferation Axis in Response to Genotoxic Stress. Human Molecular Genetics. In press.
4). Bin Xiao, Xiao Deng, Grace Lim, Shaoping Xie, Zhi Dong Zhou, and et al. Superoxide drives progression of Parkin/PINK1-dependent mitophagy following translocation of Parkin to mitochondria. Cell death and Disease. 2017. in press
5). Zhong Can Chen,,, Zhi Dong Zhou, et al. Phosphorylation of amyloid precursor protein by mutant LRRK2 promotes AICD activity and neurotoxicity in Parkinson’s disease. Science Signaling. 2017. in press
6). Lifeng Qiu, Mei-Chih Liao, Allen K Chen,, Zhi Dong Zhou, et al. Immature midbrain dopaminergic neurons derived from floor-plate method improve cell transplantation therapy efficacy for Parkinson’s disease. STEM CELLS Translational Medicine, in press.
7). Bin Xiao;, Zhi Dong Zhou; et al. p62-Mediated Mitochondrial Clustering Attenuates Apoptosis Induced by Mitochondrial Depolarization. BBA - Molecular Cell Research, 2017; 1864(7):1308-1317.
8). Murni T, Wen RJ, ,Zhi Dong Zhou, et al. Varied pathological and therapeutic response effects associated with CHCHD2 mutant and risk variants. Human mutation, 2017 Apr 21, doi: 10.1002/humu.23234.
9). Zhi Dong Zhou, Chao YX, Tan EK. Potential Implications of Mitochondrial Unfolded Protein Response in the Pathogenesis and Therapy of Dopaminergic Neuron Degeneration in Parkinson’s Disease. JSM Biotechnol Bioeng 2017; 4(1): 1075.
10), Zhi Dong Zhou* et al. Dopamine (DA) Dependent Toxicity Relevant to DA Neuron Degeneration in Parkinson’s Disease (PD). Austin Journal Of Drug Abuse And Addiction. 2016; 3(1): 1010. Corresponding author.....