Weihua Qiao, MD, PhD, is a Cardiovascular Surgeon and Associate Professor of Surgery at Union Hospital, Tongji Medical College, Huazhong University of Science and Technology. Dr. Qiao earned his medical degree from Chongqing Medical University in 2011. He obtained his PhD in the Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology with Dr. Nianguo Dong in 2016. His clinical interests include complex congenital cardiac surgery, minimally invasive cardiac surgery, and cardiac transplantation. Dr. Qiao serves as Principal Investigator on grants funded by National Key Research and Development Plan of China, National Natural Science Foundation of China, and other national/funding resources. His research is focused on biomedical materials and cardiovascular tissue engineering. Dr. Qiao has published more than 40 peer-review research papers including Circulation, European Heart Journal, Advanced Functional Materials and Acta Biomaterialia, and filed more than 10 patents. He has served as an editorial member and peer reviewer for several scientific journals in cardiovascular research and biomaterials. He has also served as mentor or advisor for a number of postdoctoral fellows, medical students, graduate and undergraduate students.

Research Interest: Biomedical materials and cardiovascular tissue engineering.

Publication List:

1. Ziwen Cai^#, Miaomiao Zhu^#, Li Xu^#, Yue Wang, Yin Xu, Wai Yen Yim, Hong Cao, Ruikang Guo, Xiang Qiu, Ximiao He, Jiawei Shi, Weihua Qiao* and Nianguo Dong*. Directed Differentiation of Human Induced Pluripotent Stem Cells to Heart Valve Cells. Circulation. 2024. DOI: 10.1161/CIRCULATIONAHA.123.065143. (Co-corresponding author).
2. Shijie Wang, Weihua Qiao*, Nianguo Dong*. Residual shunt and microthrombosis associated with new-onset migraine after transcatheter atrial septal defect closure. European Heart Journal. 2023, 44(43): 4605-4605. (Co-corresponding author).
3. Ying Zhou^#, Ge Yan^#, Shuyu Wen, Wai Yen Yim, Zihao Wang, Xing Chen, Yin Xu, Xue Chen, Hong Cao, Peng Bai, Fei Li, Jiawei Shi, Jianglin Wang, Weihua Qiao*, Nianguo Dong*. Nitric Oxide Generation and Endothelial Progenitor Cells Recruitment for Improving Hemocompatibility and Accelerating Endothelialization of Tissue Engineering Heart Valve. Advanced Functional Materials. 2023, 33(9): 2211267. (Co-corresponding author).
4. Hong Cao^#, Qian Zhou^#, Chungeng Liu, Yecen Zhang, Minghui Xie, Weihua Qiao*, Nianguo Dong*. Substrate stiffness regulates differentiation of induced pluripotent stem cells into heart valve endothelial cells. Acta Biomaterialia. 2022, 143: 115-126. (Co-corresponding author).
5. Xing Chen, Yunlong Wu, Rui Li, Chenghao Li, Li Xu*, Weihua Qiao*, Nianguo Dong*. Galactose-modified nanoparticles for delivery of microRNA to mitigate the progress of abdominal aortic aneurysms via regulating macrophage polarization. Nanomedicine: Nanotechnology, Biology and Medicine. 2022, 44: 102564. (Co-corresponding author).
6. Shuangshuang Zhu^#, Yanting Zhang^#, Weihua Qiao^#, Yixuan Wang, Yuji Xie, Xin Zhang, Chun Wu, Guohua Wan4, Yuman Li, Nianguo Dong*, Mingxing Xie*, Li Zhang*. Incremental value of preoperative right ventricular function in predicting moderate to severe acute kidney injury after heart transplantation. Frontiers in cardiovascular medicine. 2022, 9: 931517. (Co-first author).
7. Xing Chen^#, Wei-hua Qiao^#, Hong Cao^#, Jia-wei Shi, Xin-ling Du*, Nian-guo Dong*. Role of Neuroimmune Interactions in COVID-19-related Cardiovascular Damage. Current Medical Science. 2022, 42(3): 555-560. (Co-first author).
8. Shuyu Wen^#, Ying Zhou^#, Wai Yen Yim, Shijie Wang, Li Xu, Jiawei Shi, Weihua Qiao*, Nianguo Dong*. Mechanisms and Drug Therapies of Bioprosthetic Heart Valve Calcification. Frontiers in Pharmacology. 2022, 13: 909801. (Co-corresponding author).
9. Ge Yan, Yuqi Liu, Minghui Xie, Jiawei Shi, Weihua Qiao*, Nianguo Dong*. Experimental and computational models for tissue-engineered heart valves: a narrative review. Biomaterials Translational. 2021; 2(4): 361–375. (Co-corresponding author).
10. Baocheng Zhang^#, Yuan Xu^#, Sitian Ma, Linfeng Wang, Changjun Liu, Weilin Xu, Jiawei Shi, Weihua Qiao*, Hongjun Yang*. Small-diameter polyurethane vascular graft with high strength and excellent compliance            . Journal of the Mechanical Behavior of Biomedical Materials. 2021, 121: 104614. (Co-corresponding author).
11. Changjun Liu^#, Weihua Qiao^#, Chaorong Wang, Han Wang, Yingshan Zhou, Shaojin Gua, Weilin Xu, Yan Zhuang, Jiawei Shi*, Hongjun Yang*. Effect of poly (lactic acid) porous membrane prepared via phase inversion induced by water droplets on 3T3 cell behavior. International Journal of Biological Macromolecules. 2021, 183: 2205-2214. (Co-first author).
12. Chungeng Liu^#, Weihua Qiao^#, Hong Cao, Jinchi Dai, Fei Li, Jiawei Shi* and Nianguo Dong*. A riboflavin–ultraviolet light A-crosslinked decellularized heart valve for improved biomechanical properties, stability, and biocompatibility. Biomaterials Science. 2020, 8(9): 2549-2563. (Co-first author).
13. Han Wang^#, Weihua Qiao^#, Sitian Ma, Linfeng Wang, Changjun Liu, Yingshan Zhou, Shaojin Gu, Weilin Xu, Jiawei Shi*, Hongjun Yang*. Effect of temperature on the thermal property and crystallization behavior of poly (lactic acid) porous membrane prepared via phase separation induced by water microdroplets. International Journal of Biological Macromolecules. 2020, 147: 1185-1192. (Co-first author).
14. Shuyu Wen^#, Weihua Qiao^#, Yuan Zhang, and Nianguo Dong*. Development and trend in the field of valvular heart disease in China: an analysis based on the National Natural Science Foundation of China. Annals of Translational Medicine, 2020, 8(7): 449. (Co-first author).
15. Jinchi Dai^#, Weihua Qiao^#, Jiawei Shi, Chungen Liu, Xingjian Hu, Nianguo Dong. Modifying Decellularized Aortic Valve Scaffolds with Stromal Cell-derived Factor-1α Loaded Proteolytically Degradable Hydrogel for Recellularization and Remodeling. Acta Biomaterialia, 2019, 88: 280-292. (Co-first author).
16. Wei-hua Qiao^#, Peng Liu, Dan Hu, Mahmoud Al Shirbini, Xian-ming Zhou, Nian-guo Dong*. Sequential hydrophile and lipophile solubilization as an efficient method for decellularization of porcine aortic valve: structure, mechanical property and biocompatibility study. Journal of Tissue Engineering and Regenerative Medicine. 2018, 12(2): e828-e840.
17. Geng Li^#, Weihua Qiao^#, Wenjing Zhang, Fei Li, Jiawei Shi, Nianguo Dong*. The shift of macrophages toward M1 phenotype promotes aortic valvular calcification. Journal of Thoracic and Cardiovascular Surgery. 2017, 153(6): 1318-1327. e1. (Co-first author).
18. Peng Liu^#, Wei-Hua Qiao^#, Fu-Qiang Sun, Xin-Long Ruan, Mahmoud Al Shirbini, Dan Hu, Si Chen, Nian-Guo Dong*. Should a Mechanical or Biological Prosthesis Be Used for a Tricuspid Valve Replacement? A Meta-Analysis. Journal of Cardiac Surgery. 2016, 31(5): 294-302. (Co-first author).
19. Weihua Qiao^#, Nianguo Dong, Peng Liu, Dan Hu, Fayuan Liu, Jiawei Shi. Perfusion decellularization method for the fabrication of decellularized porcine aortic valve scaffold. Chinese Journal of Experimental Surgery. 2016, 33(4): 1023-1025. (Chinese journal)
20. Weihua Qiao^#, Peng Liu, Jiawei Shi, Yin Wang, Nianguo Dong. Changes of Left Ventricular Morphology and Contractile Function after Mitral Valve Replacement of Patients with Mitral Stenosis and Small Left Ventricle: A Meta-analysis. Chinese Journal of Clinical Thoracic and Cardiovascular Surgery. 2016, 23(6): 589-594. (Chinese journal)
21. Weihua Qiao^#, Nianguo Dong, Jiawei Shi. Meta-Analysis of the Association between TBX1 Gene Mutation and Conotruncal Defects. Chinese Journal of Practical Pediatrics. 2014, 29(9): 677-680. (Chinese journal)
22. Weihua Qiao^#, Nianguo Dong. Is there an age limit for the use of biologic valve? Journal of Clinical Cardiology. 2014, 30(9): 745-748. (Chinese journal)
23. Shuyu Wen, Ying Zhou, Weihua Qiao, Yixuan Wang, Jing Zhang, Nianguo Dong. Infant heart transplantation with extremely oversized donor heart: is the donor–recipient size matching too conservative?. ESC Heart Failure. 2023, 10(2): 1431-1434.
24. Yuanming Li, Ying Zhou, Weihua Qiao, Jiawei Shi, Xuefeng Qiu*, Nianguo Dong*. Application of decellularized vascular matrix in small-diameter vascular grafts. Frontiers in Bioengineering and Biotechnology. 2023, 10: 1081233.
25. Yuqi Zheng, Shuyu Wen, Shijiu Jiang, Shaolin He, Weihua Qiao, Yi Liu, Wenling Yang, Jin Zhou, Boyuan Wang, Dazhu Li, Jibin Lin. CircRNA/lncRNA-miRNA-mRNA network and gene landscape in calcific aortic valve disease. BMC genomics. 2023, 24(1): 419.
26. Yuqi Chen, Zongtao Liu, Fayuan Liu, Li Xu, Geng Li, Weihua Qiao, Yixuan Wang, Nianguo Dong. T cell specific deletion of IRF4 with Ox40-Cre impairs effector and memory T cell responses in heart transplantation. Clinical Immunology. 2023, 252: 109647.
27. Xue Chen, Nianguo Dong, Xu Xu, Ying Zhou, Jiawei Shi, Weihua Qiao, Hao Hong. Re-endothelialization of Decellularized Scaffolds With Endothelial Progenitor Cell Capturing Aptamer: A New Strategy for Tissue-Engineered Heart Valve. ASAIO Journal. 2023, 69(9): 885-893.
28. Shuyu Wen, Weihua Qiao, Nianguo Dong. Current status and progress of aortic valve surgery treatment. Journal of Clinical Cardiology. 2023, 39(6): 417-424. (Chinese journal)
29. Peng Bai, Gangcheng Kong, Weihua Qiao, Yu Song, Yixuan Wang, Jiawei Shi, Nan Zhang, Chungeng Liu, Chong Chu, Tixiusi Xiong, Ying Zhou, Cuifen Lu, Lin Wang, Nianguo Dong. A Novel Method to Improve the Physical Property and Biocompatibility of Decellularized Heart Valve Scaffold with Sericin and Polydopamine. Journal of Bionic Engineering. 2022, 19(4): 1109-1123.
30. Chanchan Song, Linli Wang, Qingyang Li, Baoyi Liao, Weihua Qiao, Qiang Li, Nianguo Dong, Liangping Li. Generation of individualized immunocompatible endothelial cells from HLA-I-matched human pluripotent stem cells. Stem cell research & therapy. 2022, 13(1): 1-17.
31. Ming-Hui Xie, Wei-Hua Qiao, Hong Cao, Jia-Wei Shi, Nian-Guo Dong. Progress in the Role of Mechanical Stimulus in Cardiac Development. Acta Academiae Medicinae Sinicae. 2022, 44(1): 164-172. (Chinese journal)
32. Peng Liu, Dong-Sheng Xia, Wei-Hua Qiao, Dan Hu, Adnan Ahmed, Nian-Guo Dong, Si Chen. Which is the best prosthesis in an isolated or combined tricuspid valve replacement?. European Journal of Cardio-Thoracic Surgery. 2021, 59(1): 170-179.
33. Shuangshuang Zhu, Yuji Xie, Weihua Qiao, Fangyan Tian, Wei Sun, Yixuan Wang, Chun Wu, He Li, Luyang Yi, Yi Zhong, Nianguo Dong, Yuman Li, Mingxing Xie, Li Zhang. Impaired left atrial function in clinically well heart transplant patients. The International Journal of Cardiovascular Imaging. 2021, 37: 1937-1945.
34. LinXi Cheng, MingHui Xie, WeiHua Qiao, Yu Song, YanYong Zhang, YingChao Geng, WeiLin Xu, Lin Wang, Zheng Wang, Kai Huang, NianGuo Dong, YuHua Sun. Generation and characterization of cardiac valve endothelial-like cells from human pluripotent stem cells. Communications Biology. 2021, 4(1): 1039.
35. Qin WANG, Yuzhi QIU, Weihua QIAO, Nianguo DONG, Yajiang YANG. Gelation Systems and Mechanisms of Chondroitin Sulfate-Based Injectable Hydrogels. Journal of Functional Polymers. 2021, 34(3): 243-259. (Chinese journal)
36. Shuyu Wen, Weihua Qiao, Nianguo Dong. Applications of enhanced recovery after surgery in cardiovascular surgery. Journal of Clinical Cardiology. 2021, 37(9): 787-790. (Chinese journal)
37. Ge YAN, Wei-hua QIAO, Hong CAO, Jia-wei SHI, Nian-guo DONG. Application of surface modification of polydopamine in tissue engineering. China Biotechnology. 2021, 40(12): 75-81. (Chinese journal)
38. Shuangshuang Zhu, Wei Sun, Weihua Qiao, Meng Li, Yuman Li, Bo Liang, Jing Wang, Nianguo Dong, Li Zhang, Mingxing Xie. Real time three-dimensional echocardiographic quantification of left atrial volume in orthotopic heart transplant recipients: Comparisons with cardiac magnetic resonance imaging. Echocardiography. 2020, 37(8): 1243-1250.
39. Peng Bai, Weihua Qiao, Nan Zhang, Chungen Liu, Jiawei Shi, Nianguo Dong. Advances in research on recellularization of tissue engineered heart valves based on decellularized matrix. Acta Medicinae Universitatis Scientiae et Technologiae Huazhong. 2018, 47(2): 244-250. (Chinese journal)
40. Huadong Li, Jiawei Shi, Weihua Qiao, Nianguo Dong, Gangjian Qin. Abstract 43: SIRT1 Enhances Oxidized Low-density Lipoprotein Induced Autophagy in Human Valve Interstitial Cells. Circulation Research. 2016, 119(suppl_1).
41. Qi Liu^#, Wei-Hua Qiao, Fei-fei Li, Peng Deng, and Zhi-wei Hu*. The Role of Interleukin-13 in Patients with Rheumatic Valvular Fibrosis: A Clinical and Histological Study. Journal of Heart Valve Disease. 2015, 24(4):496-501.