In 2009, graduated from Tianjin Medical University with a Ph.D. in immunology. In the same year, began to work in the Institute of Ophthalmology of Tianjin Medical University, where worked as a basic researcher. In 2012, went to Germany for a one-year postdoctoral research. Up to now, has undertaken and completed three national and provincial-level projects, and published a total of 66 research papers.

Research Interest:

PSF signalling pathway

Ocular neovascularization disease

Experimental autoimmune uveitis (EAU)

Mesenchymal stem cell therapy

Dentritic cells maturation and migration

Grants:

•  as a project principal: PTB-associated splicing factor (PSF) functions as a repressor of HIF-1α-mediated VEGF gene transcription by recruitment of Hakai. (NSFC Granted NO. 81570872,2016-2019)

•  as a project principal: the molecular mechanism of transcriptional inhibitor PSF suppress Human retinal microvessal endothelial cells proliferation with IGF-1 stimulation. (NSFC Granted NO. 31100991,2012-2014)

•  as the participant :Identification the miRNAs related with the differentiation of ESCs into RPE cells and theit effect on JUN passway. (NSFC Granted NO. 30973255, 2011-2013)

List of Publications:

1.  Dong, L., Zhang, X., Fu, X., Zhang, X., Gao, X., Zhu, M., . . . Yang, J. (2011). PTB-associated splicing factor (PSF) functions as a repressor of STAT6-mediated Ig epsilon gene transcription by recruitment of HDAC1. J Biol Chem, 286(5), 3451-3459. doi:10.1074/jbc.M110.168377（co-first author）

2.  Liu, X., Dong, L., Zhang, X., Wang, B., Wang, X., Li, H., . . . Yang, J. (2011). Identification of p100 target promoters by chromatin immunoprecipitation-guided ligation and selection (ChIP-GLAS). Cell Mol Immunol, 8(1), 88-91. doi:10.1038/cmi.2010.47（co-first author）

3.  WB, L., MW, M., LJ, D., F, W., LX, C., biology, L. X. J. C., & therapy. (2011). MicroRNA-34a targets notch1 and inhibits cell proliferation in glioblastoma multiforme. 12(6), 477-483. (co-author)

4.  Li WB, Z. Y., Lu ZY,  Dong LJ,  Wang FE,  Dong R,  Li XR. (2012). Development of retinal pigment epi thelium from human parthenogenetic embryonic stem cells and microRNA signature. Invest. Ophthalmol. Vis. Sci., 53(9). doi:10.1167/iovs.12-8303  (co-author)

5.  LJ, Z., Y, Z., LJ, D., & ophthalmology, L. X. J. C. j. o. (2012). [Expression and function of microRNA in the eye]. 48(12), 1136-1140. (co-author)

6.  Tian, F., Dong, L., Zhou, Y., Shao, Y., Li, W., Zhang, H., & Wang, F. (2014). Rapamycin-Induced apoptosis in HGF-stimulated lens epithelial cells by AKT/mTOR, ERK and JAK2/STAT3 pathways. Int J Mol Sci, 15(8), 13833-13848. doi:10.3390/ijms150813833（co-first author）

7.   Wei, R., Dong, L., Xiao, Q., Sun, D., Li, X., & Nian, H. (2014). Engagement of Toll-like receptor 2 enhances interleukin (IL)-17(+) autoreactive T cell responses via p38 mitogen-activated protein kinase signalling in dendritic cells. Clin Exp Immunol, 178(2), 353-363. doi:10.1111/cei.12405（co-first author）

8.  Zhang, L., Dong, L., Liu, X., Jiang, Y., Zhang, L., Zhang, X., . . . Zhang, Y. (2014). alpha-Melanocyte-stimulating hormone protects retinal vascular endothelial cells from oxidative stress and apoptosis in a rat model of diabetes. PLoS One, 9(4), e93433. doi:10.1371/journal.pone.0093433 (co-author)

9.  Zhang, L., Zheng, H., Shao, H., Nian, H., Zhang, Y., Bai, L., . . . Zhang, X. (2014). Long-term therapeutic effects of mesenchymal stem cells compared to dexamethasone on recurrent experimental autoimmune uveitis of rats. Invest Ophthalmol Vis Sci, 55(9), 5561-5571. doi:10.1167/iovs.14-14788 (co-author)

10.  T, L., L, Z., B, Z., L, X., J, L., L, D., & reports, H. Y. J. O. (2015). Establishment and characterization of a cell line from human adenoid cystic carcinoma of the lacrimal glands and a nude mouse transplantable model. 33(6), 2797-2806. (co-author)

11.  Dong, L., Nian, H., Shao, Y., Zhang, Y., Li, Q., Yi, Y., . . . Li, X. (2015). PTB-associated splicing factor inhibits IGF-1-induced VEGF upregulation in a mouse model of oxygen-induced retinopathy. Cell Tissue Res, 360(2), 233-243. doi:10.1007/s00441-014-2104-5 (the first author)

12.  Shao, Y., Dong, L. J., Zhang, Y., Liu, H., Hu, B. J., Liu, J. P., & Li, X. R. (2015). Surgical induced astigmatism correlated with corneal pachymetry and intraocular pressure: transconjunctival sutureless 23-gauge versus 20-gauge sutured vitrectomy in diabetes mellitus. Int J Ophthalmol, 8(3), 528-533. doi:10.3980/j.issn.2222-3959.2015.03.16 （co-first author）

13.  Y, S., C, S., JT, W., B, D., LJ, D., AH, L., . . . medicine, e. (2015). Temporal and spatial changes in VEGF, αA- and αB-crystallin expression in a mouse model of oxygen-induced retinopathy. 8(3), 3349-3359. (co-author)

14.  PT, Z., LJ, Z., H, S., LL, B., B, Y., C, S., . . . ophthalmology, Z. X. J. I. j. o. (2016). Therapeutic effects of mesenchymal stem cells administered at later phase of recurrent experimental autoimmune uveitis. 9(10), 1381-1389. (co-author)

15.  W, L., L, D., M, M., B, H., Z, L., X, L., . . . therapy. (2016). Preliminary in vitro and in vivo assessment of a new targeted inhibitor for choroidal neovascularization in age-related macular degeneration. 10(undefined), 3415-3423.（co-first author）

16.  X, C., H, S., Y, Z., Q, X., C, S., L, D., . . . development. (2016). CD73 Pathway Contributes to the Immunosuppressive Ability of Mesenchymal Stem Cells in Intraocular Autoimmune Responses. 25(4), 337-346. (co-author)

17.  H, T., LY, H., F, T., LJ, D., & ophthalmology, Z. H. J. C. j. o. (2017). [Effects of SMP-30 overexpression on apoptosis of human lens epithelial cells induced by ultraviolet B irradiation]. 53(11), 835-841. (co-author)

18.  L, B., H, S., H, W., Z, Z., C, S., L, D., . . . reports, Z. X. J. S. (2017). Effects of Mesenchymal Stem Cell-Derived Exosomes on Experimental Autoimmune Uveitis. 7(1), 4323. (co-author)

19.  X, W., Y, Z., L, Z., R, W., & vision, D. L. J. M. (2017). Comparison of fibrin glue and Vicryl sutures in conjunctival autografting for pterygium surgery. 23(undefined), 275-285. (co-author)

20.  L, D., X, C., H, S., L, B., X, L., & medicine, Z. X. J. C. m. (2018). Mesenchymal Stem Cells Inhibited Dendritic Cells Via the Regulation of STAT1 and STAT6 Phosphorylation in Experimental Autoimmune Uveitis. 17(7), 478-487. (the first author)

21.  T, M., LJ, D., XL, D., R, N., & ophthalmology, H. B. J. I. j. o. (2018). Research progress on the role of connective tissue growth factor in fibrosis of diabetic retinopathy. 11(9), 1550-1554.

22.  X, X., L, H., Y, L., X, L., R, S., X, L., & research, D. L. J. C. e. (2019). DL-3-n-butylphthalide Protected Retinal Müller Cells Dysfunction from Oxidative Stress. undefined(undefined), 1-9. (co-author)

23.  Y, S., LJ, D., Y, T., J, C., X, L., Q, C., . . . metabolism. (2019). miRNA-451a regulates RPE function through promoting mitochondrial function in proliferative diabetic retinopathy. 316(3), E443-E452. （co-first author）

24.  G, S., R, H., L, Z., X, S., K, H., L, D., . . . failure, K. Y. J. R. (2019). The effect of hemodialysis on ocular changes in patients with the end-stage renal disease. 41(1), 629-635. (co-author)