I got a Ph.D. degree (Radiology) at Seoul National University, which is Top of University in Korea, and got a Post Doc training in the Department of Radiology at University of Pennsylvania.  To date, my studies have focused on the development of new biomarkers for diagnosis& therapeutic approach, and evaluation their ability by in vitro and in vivo experiments related with tumor and neuroscience. These day, I’m working to learn about a new therapeutic approach using alpha and beta emitted radioisotope labeled biomarker, quality control, drug formulation and stability.

Research Interest: I am an expert in the fields of molecular imaging (PET, SPECT, CT, MRI, IVIS, microscope, confocal image), CDX modelling, radio-isotope related research, set up the assay protocol (Kd, Bmax, Ki), drug screening, validation of new biomarker by in vitro assay and in vivo experiments, ADME, and analysis of data. It was provided by peer-reviewed paper publication on molecular biology, radiology, and neuroscience fields. I’m interested in the development of new biomarkers for diagnosis and therapy, the binding mechanism of biomarkers, understanding pharmacological profiles of biomarkers, and estimating possibility of therapeutic use for clinical approach. Based on expanding skills and knowledge, I would like to contribute in the field of the development of new biomarkers for diagnosis and therapy by in vitro and in vivo studies.

Publications List:

1. Ji Youn Lee, et all. “In vitro characterization of [125I]HY-3-24, a selective ligand for the dopamine  D3 receptor” March 2024, Accepted in Frontiers In Neuroscience.
2. Gui-Long Tian, Chia-Ju Hsieh, Michelle Taylor, Ji Youn Lee, et all. “Synthesis of bitopic ligands  based on fallypride and evaluation of their affinity and selectivity towards dopamine D2 and D3 receprots” Eur J Med Chem 2023 Dec 261:115751.
3. Kim, Ho Young; Lee, Ji Youn, et all. “Design and synthesis of conformationally-flexible scaffold based bitopic ligands for potent D3 selective antagonists" Int J Mol Sci 2022 Dec;24(1):432.
4. Mehran Makvandi, Minu Samanta, Paul Martorano, Hwan Lee, Sarah Gitto, Khusbu Patel, David  Groff, Jennifer Pogoriler, Daniel Martinez, Aladin Riad, Hannah Dabagian, Michael Zaleski, Tahereh  Taghvaee, Kuiying Xu, Ji Youn Lee, et all. “Pre-clinical investigation of astatine-211-parthanatine for  high-risk neuroblastoma” Communication Biology, 2022 Nov 5(1):1260.
5. Chia-Ju Hsieh, Catherine Hou, Yi Zhu, Ji Youn Lee, et all “[18F]ROStrace detects oxidative stress  in  ivo and predicts progression of Alzheimer’s disease pathology in APP/PS1 mice” EJMMI Res 2022  Jul 27;12(1):43.
6. Kuiying Xu, Chia-Ju Jsieh, Ji Youn Lee, et al “Exploration of Diazaspiro Cores as Piperazine  Bioisosteres in the Development of σ2 Receptor Ligands” Int J Mol Sci. 2022 Jul 27;23(15):8259.
7. Kim, Ho Young; Lee, Ji Youn, et al. “Screening of σ2 receptor ligands and in vivo evaluation of  11C-labeled 6,7-dimethoxy-2-(4-(4-methoxyphenyl)butan-2-yl)-1,2,3,4-tetrahydroisoquinoline for  potential use as σ2 receptor brain PET tracer" JMC. 2022,65;8:6261-6272.
8. Laura N Puentes, Zsofia Lengyel-Zhand, Ji Youn Lee, et al “Poly (ADP-ribose) induces α-synuclein  aggregation in neuronal-like cells and interacts with phosphorylated α-synuclein in post mortem PD  samples” Front Aging Neurosci. 2021 Jun 18;13:704041.
9. CJ Hsieh, A Riad, Ji Youn Lee, et al “Interaction of ligands for PET with the dopamine D3 receptor:  In silico and In vitro methods” Biomolecules 2021 Apr 2;11(4), 529.
10. Xiao-Yang Xie, Yu-Yun Li, Wen-Hui Ma, Ai-fang Chen, Yu-Tong Sun, Ji Youn Lee, et al “Synthesis,  inding, and functional properties of tetrahydroisoquinolino-2-alkyl phenones as selective sigma 2  /TMEM97 ligands” Eur J Med Chem. 2020;7;209;112906.
11. Ji Youn Lee, et al “Preparation of a multi-modal agent for sentinel lymph node mapping using Evans blue and 99mTc-labeled mannosylated human serum albumin conjugate” Nucl Med Biol. 2020;84-5:38-45.
12. Park JY, Kim YJ, Lee JY, et al “Imaging of the third gasotransmitter hydrogen sulfide using 99mTclabeled alpha-hydroxy acids” Nucl Med Biol. 2019;76-77:28-35.
13. Kim HY, Lee JY, et al “Design and synthesis of enantiopure 18F-labelled  [18F]trifluoromethyltryptophan from 2-halotryptophan derivatives via copper(I)-mediated  [18F]trifluoromethylation and evaluation of its in vitro characterization for the serotonergic system  imaging.” J Labelled Comp Radiopharm. 2019;62(9);566-579.
14. Lee JY, et al “Naphthol Blue Black and 99mTc-Labeled Mannosylated Human Serum Albumin  (99mTc-MSA) Conjugate as a Multimodal Lymph Node Mapping Nanocarrier” Sci Rep  2018;11;8(1);13636.
15. Kim HY, Park C, Lee JY, et al. “One-pot radiosynthesis of O-[(18)F]fluoromethyl-D-tyrosine via  intra-molecular nucleophilic (18)F-fluorination with 1,2,3-triazolium triflate salt precursor.” Appl  Radiat Isot. 2018;132:105-9.
16. Lee B, Kim YK, Lee JY, et al. “Preclinical anaylses of [(18)F]cEFQ as a PET tracer for imaging  metabotropic glutamate receptor type 1 (mGluR1).” J Cereb Blood Flow Metab. 2017;37(6):2283-93. Seo HJ, Nam SH, Im HJ, Park JY, Lee JY, et al. “Rapid Hepatobiliary Excretion of  icelleEncapsulated/Radiolabeled Upconverting Nanoparticles as an Integrated Form.” Sci Rep.  015;5:15685.
17. Seelam SR, Lee JY, et al. “Development of (68)Ga-labeled multivalent nitroimidazole derivatives  for hypoxia imaging.” Bioorg Med Chem. 2015;23(24):7743-50.
18. Lee JY, et al. “Development of 68Ga-human serum albumin as a PET imaging agent for diagnosis of acute inflammation.” Journal of radiopharmaceuticals and molecular probes. 2015;1(2):104-8.
19. Lee JY, et al. “Preparation of Ga-68-NOTA as a renal PET agent and feasibility tests in mice.” Nucl  Med Biol. 2014;41(2):210-5.
20. Shetty D, Jeong JM, Kim YJ, Lee JY, et al. “Development of a bifunctional chelating agent  containing isothiocyanate residue for one step F-18 labeling of peptides and application for RGD labeling.” ioorg Med Chem. 2012;20(19):5941-7.
21. Hoigebazar L, Jeong JM, Lee JY, et al. “Syntheses of 2-nitroimidazole derivatives conjugated with  1,4,7-triazacyclononane-N,N'-diacetic acid labeled with F-18 using an aluminum complex method for  hypoxia imaging.” J Med Chem. 2012;55(7):3155-62.
22. Hoigebazar L, Jeong JM, Hong MK, Kim YJ, Lee JY, et al. “Synthesis of 68Ga-labeled OTAnitroimidazole derivatives and their feasibilities as hypoxia imaging PET tracers.” Bioorg Med Chem. 2011;19(7):2176-81.
23. Shetty D, Choi SY, Jeong JM, Lee JY, et al. “Stable aluminium fluoride chelates with triazacyclononane derivatives proved by X-ray crystallography and 18F-labeling study.” Chem Comm. 2011;47(34):9732-4.
24. Shetty D, Jeong JM, Ju CH, Kim YJ, Lee JY, et al. “Synthesis and evaluation of macrocyclic amino acid derivatives for tumor imaging by gallium-68 positron emission tomography.” Bioorg Med Chem. 2010;18(21):7338-4.