Irmak Ferah Okkay

Designation:

Associate Professor

Department:

Pharmacology

University:

Ataturk University

Country:

Turkey

Email:

irmakfrh@gmail.com

Journal Associated: Advances in Toxicology and Toxic Effects Biography:

Irmak FERAH OKKAY is an Assoc. Prof. of Pharmacology at "Ataturk University, School of Pharmacy, Erzurum, Turkey. She received her MS degree in Medical Pharmacology in 2012 from the Ataturk University. In 2015, she obtained her PhD in Medical Pharmacology at the Ataturk University. Her research is focused on experimental animal models. In particular, Dr. FERAH OKKAY is interested in in vitro and in vivo models of neurodegenerative disorders. Dr. FERAH OKKAY is teaching basic pharmacology, pharmacokinetics, drug development and toxicology to pharmacy students, undergraduates and graduate students. She has published more than 30 international publications and four book chapters. She is a member of the Turkish Pharmacological Society. In addition, she is also serving as reviewer to several journals.

Research Interests: Pharmacology, neuroscience, drug discovery, toxicology and applied pharmacology, molecular biology, molecular mechanisms, cell culture, animal models.

Publication List:

Ferah Okkay I, Okkay U, Cicek B, Karatas O, Yilmaz A, Yesilyurt F, Hacimuftuoglu A. Syringic acid guards against indomethacin-induced gastric ulcer by alleviating inflammation, oxidative stress and apoptosis. Biotech Histochem. 2024 Apr 22:1-10. doi: 10.1080/10520295.2024.2344477.
Birdal O, Ferah Okkay I, Okkay U, Bayram C, Mokthare B, Ertugrul MS, Hacimuftuoglu A, Aksakal E, Koza Y, Saygi M, Senocak H. Protective effects of arbutin against doxorubicin-induced cardiac damage. Mol Biol Rep. 2024 Apr 18;51(1):532. doi: 10.1007/s11033-024-09488-4. PMID: 38637360.
Bayraktar M, Hacımüftüoğlu A, Okkay U, Koçak MN, Kösedağ M, Tekin E, Çelik M, Ferah Okkay I, Bayram C, Ertuğrul MS, Sezen S. Use of bee venom in preventive medicine: An experimental hepatic encephalopathy study in rats. Vet Med Sci. 2024 Jan;10(1):e1336. doi: 10.1002/vms3.1336.
Sezen S, Ertuğrul MS, Balpınar Ö, Bayram C, Özkaraca M, Ferah Okkay I, Hacımüftüoğlu A, Güllüce M. Assessment of antimicrobial activity and in vitro wound healing potential of ZnO nanoparticles synthesized with Capparis spinosa extract. Environ Sci Pollut Res Int. 2023 Nov;30(55):117609-117623. doi: 10.1007/s11356-023-30417-8.
Ferah Okkay I, Okkay U, Bayram C, Cicek B, Sezen S, Aydin IC, Mendil AS, Hacimuftuoglu A. Bromelain protects against cisplatin-induced ocular toxicity through mitigating oxidative stress and inflammation. Drug Chem Toxicol. 2023 Jan;46(1):69-76. doi: 10.1080/01480545.2021.2011308.
Okkay U, Ferah Okkay I, Cicek B, Aydin IC, Ozkaraca M. Hepatoprotective and neuroprotective effect of taxifolin on hepatic encephalopathy in rats. Metab Brain Dis. 2022 Jun;37(5):1541-1556. doi: 10.1007/s11011-022-00952-3.
Ferah Okkay I, Okkay U, Aydin IC, Bayram C, Ertugrul MS, Mendil AS, Hacimuftuoglu A. Centella asiatica extract protects against cisplatin-induced hepatotoxicity via targeting oxidative stress, inflammation, and apoptosis. Environ Sci Pollut Res Int. 2022 May;29(22):33774-33784. doi: 10.1007/s11356-022-18626-z.
Ferah Okkay I, Okkay U, Gundogdu OL, Bayram C, Mendil AS, Ertugrul MS, Hacimuftuoglu A. Syringic acid protects against thioacetamide-induced hepatic encephalopathy: Behavioral, biochemical, and molecular evidence. Neurosci Lett. 2022 Jan 19;769:136385. doi: 10.1016/j.neulet.2021.136385.
Ferah Okkay I, Okkay U, Cicek B, Yilmaz A, Yesilyurt F, Mendil AS, Hacimuftuoglu A. Neuroprotective effect of bromelain in 6-hydroxydopamine induced in vitro model of Parkinson's disease. Mol Biol Rep. 2021 Dec;48(12):7711-7717. doi: 10.1007/s11033-021-06779-y.
Okkay U, Ferah Okkay I, Aydin IC, Bayram C, Ertugrul MS, Gezer A, Hacimuftuoglu A. Effects of Achillea millefolium on cisplatin induced ocular toxicity: an experimental study. Cutan Ocul Toxicol. 2021 Sep;40(3):214-220. doi: 10.1080/15569527.2021.1919137.
Okkay U, Ferah Okkay I, Cicek B, Aydin IC, Ertugrul MS, Bayram C, Senyayla S, Sezen S, Mendil AS, Guven L, Hacimuftuoglu A. Achillea millefolium alleviates testicular damage in paclitaxel-intoxicated rats via attenuation of testicular oxido-inflammatory stress and apoptotic responses. Andrologia. 2021 Jun;53(5):e14028. doi: 10.1111/and.14028.
Ferah Okkay I, Cicek B. Investigation of the Effects of Pregnenolone Against Oxidative Stress Induced by Anticancer Drug Paclitaxel in Rats. Neuroendocrinology. 2021 Apr;111 (1): 26-27.
Ahiskali I, Ferah Okkay I, Mammadov R, Okkay U, Keskin Cimen F, Kurt N, Suleyman H. Effect of taxifolin on cisplatin-associated oxidative optic nerve damage in rats. Cutan Ocul Toxicol. 2021 Mar;40(1):1-6. doi: 10.1080/15569527.2020.1844726.
Calikoglu C, Cakir M, Kutlu Kotan Z, Ozdemir G, Özel L, Ferah I. Should we use the serum vaspin level for the diagnosis and/or prognosis of subarachnoid hemorrhage? J Neurosurg Sci. 2017 Oct;61(5):481-485. doi: 10.23736/S0390-5616.16.03163-X.
Ziypak T, Halici Z, Alkan E, Akpinar E, Polat B, Adanur S, Cadirci E, Ferah I, Bayir Y, Karakus E, Mercantepe T. Renoprotective effect of aliskiren on renal ischemia/reperfusion injury in rats: electron microscopy and molecular study. Ren Fail. 2015 Mar;37(2):343-54. doi: 10.3109/0886022X.2014.991327.
Aydin A, Halici Z, Akoz A, Karaman A, Ferah I, Bayir Y, Aksakal AM, Akpinar E, Selli J, Kovaci H. Treatment with α-lipoic acid enhances the bone healing after femoral fracture model of rats. Naunyn Schmiedebergs Arch Pharmacol. 2014 Nov;387(11):1025-36. doi: 10.1007/s00210-014-1021-1.
Şengül Ö, Dilbaz B, Halıcı Z, Ferah I, Çadırcı E, Yılmaz F. Decreased serum nesfatin-1 levels in endometriosis. Eur J Obstet Gynecol Reprod Biol. 2014 Jun;177:34-7. doi: 10.1016/j.ejogrb.2014.03.012.
Orsal E, Halici Z, Bayir Y, Cadirci E, Bilen H, Ferah I, Aydin A, Ozkanlar S, Ayan AK, Seven B, Ozaltin S. The role of carnitine on ovariectomy and inflammation-induced osteoporosis in rats. Exp Biol Med (Maywood). 2013 Dec;238(12):1406-12. doi: 10.1177/1535370213502614.
Sengul O, Ferah I, Polat B, Halici Z, Bayir Y, Yilmaz M, Kilic N, Keles ON. Blockade of endothelin receptors with bosentan limits ischaemia/reperfusion-induced injury in rat ovaries. Eur J Obstet Gynecol Reprod Biol. 2013 Oct;170(2):458-63. doi: 10.1016/j.ejogrb.2013.06.040.
Bilen H., Ferah I., Yayla M., Vançelik S., Halici Z. Novel approaches for the treatment of paracetamol induced liver injury. Wulfenia. 2013 Jan; 20(10).
Ferah I, Halici Z, Bayir Y, Demirci E, Unal B, Cadirci E. The role of infliximab on paracetamol-induced hepatotoxicity in rats. Immunopharmacol Immunotoxicol. 2013 Jun;35(3):373-81. doi: 10.3109/08923973.2013.775589.
Karakus E, Halici Z, Albayrak A, Bayir Y, Aydin A, Unal D, Cadirci E, Ferah I, Odaci E. Beneficial pharmacological effects of levosimendan on antioxidant status of acute inflammation induced in paw of rat: involvement in inflammatory mediators. Basic Clin Pharmacol Toxicol. 2013 Mar;112(3):156-63. doi: 10.1111/bcpt.12004.
Bayir Y, Halici Z, Karakus E, Albayrak A, Ferah I, Kabalar E, Keles O, Keles MS, Unal B. Comparing effects of lacidipine, ramipril, and valsartan against experimentally induced myocardial infarcted rats. Cardiovasc Toxicol. 2012 Jun;12(2):166-74. doi: 10.1007/s12012-012-9156-0. PMID: 22318742.
Cadirci E, Halici Z, Odabasoglu F, Albayrak A, Karakus E, Unal D, Atalay F, Ferah I, Unal B. Sildenafil treatment attenuates lung and kidney injury due to overproduction of oxidant activity in a rat model of sepsis: a biochemical and histopathological study. Clin Exp Immunol. 2011 Dec;166(3):374-84. doi: 10.1111/j.1365-2249.2011.04483.x.