Fengqi Hao received the B.S. and M.S. degrees in Animal Science and Preventive veterinary medicine from Jilin Agricultural University, China, in 2005 and 2008, respectively. Then, he joined the faculty of Department of Life Science and Technology at the Changchun University of Science and Technology, China, where he focused on the mechanistic investigation on intestinal immunoloregulation. From 2013 to 2018, Fengqi Hao completed the doctoral works at Northeast Normal University, China, and received the Ph.D. degree in Biology, specializing in Biochemistry & Molecular Biology. During this period, his major works in the area of cell metabolic regulation involves illustrating the mechanisms of fatty acid metabolism and Warburg effect in determination of cell fate, such as regulatory T cell differentiation, dendritic cell activation, and tumor cell proliferation.

Research Interest: Based on the previous research experience, he currently focuses on the molecular mechanism underling exercise-induced health improvement from the perspective of cellular metabolism: 1) exerkines mediates metabolic reprograming for skeletal muscle satellite cells differentiation to support skeletal muscle regeneration, 2) metabolites from carbohydrate, fatty acid and amino acids regulate proliferation or differentiation of immune cells for balancing immune homeostasis.

 Publications List:

1. Chaoyi Xia, Xiyue Xing, Wenxia Zhang, Yang Wang, Xin Jin, Yang Wang, Meihong Tian*, Xueqing Ba*, Fengqi Hao*. Cysteine and homocysteine can be exploited by GPX4 in ferroptosis inhibition independent of GSH synthesis. Redox Biol. 2024; 69: 102999.
2. Fengqi Hao, Miaomiao Tian, Huiyue Wang, Shuo Li, Xinyu Wang, Xin Jin, Yang Wang, Yang Jiao*, Meihong Tian*. Exercise-induced β-hydroxybutyrate promotes Treg cell differentiation to ameliorate colitis in mice. FASEB J. 2024; 38(4): e23487.
3. Fengqi Hao, Miaomiao Tian, Xinbo Zhang, Xin Jin, Ying Jiang, Xue Sun, Yang Wang, Pinghui Peng, Jia Liu, Chaoyi Xia, Yunpeng Feng*, Min Wei*. Butyrate enhances CPT1A activity to promote fatty acid oxidation and iTreg differentiation. Proc Natl Acad Sci U S A. 2021, 118(22): e2014681118.
4. Miaomiao Tian, Fengqi Hao (Co-first author), Xin Jin, Xue Sun, Ying Jiang, Yang Wang, Dan Li, Tianyi, Yingying Zou, Pinghui Peng, Chaoyi Xia, Jia Liu, Yuanxi Li, Ping Wang, Yunpeng Feng*, Min Wei*. ACLY ubiquitination by CUL3-KLHL25 induces the reprogramming of fatty acid metabolism to facilitate iTreg differentiation. Elife. 2021, 10: e62394.
5. Jianyong Wang, Miaomiao Tian, Wei Li, Fengqi Hao*. Preventative delivery of IL-35 by Lactococcus lactis ameliorates DSS-induced colitis in mice. Appl Microbiol Biotechnol. 2019, 103 (19): 7931-7941.
6. Fengqi Hao, MiaomiaoTian, Yunpeng Feng, Chao Quan, Yixi Chen, Shuai Chen, Min Wei*. Abrogation of Lupus Nephritis in Somatic Hypermutation-Deficient MRL/lpr Mice. J Immunol. 2018, 200 (12): 3905-3912. 2
7. Xin Jin, Wenxia Zhang, Yang Wang, Jia Liu, Fengqi Hao, Yunlong Li, Miaomiao Tian, Hengyao Shu, Jiaxin Dong, Yunpeng Feng*, Min Wei*. Pyruvate Kinase M2 Promotes the Activation of Dendritic Cells by Enhancing IL-12p35 Expression. Cell Rep. 2020 31(8):107690.
8. Yang Wang, Jai Liu, Xin Jin, Dapeng Zhang, Dongxue Li, Fengqi Hao, Yunpeng Feng, Shan Gu, Fanlin Meng, Miaomiao Tia, Yi Zheng, Ling Xin, Xinbo Zhang, Xue Han, Aravind L, Min Wei*. O-GlcNAcylation destabilizes the active tetrameric PKM2 to promote the Warburg effect. Proc Natl Acad Sci U S A. 2017, 114(52):13732-13737.
9. Guilin Zhang, Pengyu Zhang, Wei Li*, Fengqi Hao, Fangmei Chen, Yu Yang, Yue Hou, Yuting Tao. Reduction of gut microbial diversity and short chain fatty acids in BALB/c mice exposure to microcystin-LR. Ecotoxicology. 2020, 29(9):1347-1357.