Dr. Anna Palumbo is currently Research Director at the Stazione Zoologica Anton Dohrn. She spent some periods  abroad, at INSERM and INSA in France and, as visiting scientist, at NIH, Bethesda and at MRC, Edinburgh. Dr. Anna Palumbo has authored and co-authored several international publications and also working as a reviewer for reputed professional journals. Her research interests are mainly focused on marine organisms. In particular, she investigated the biosynthesis, signalling and roles of nitric oxide in relation to cuttlefish  defence system and ascidian development. More recently, research interests have been focused to understand how marine organisms are responding and may adapt to the increasing pressure exerted by climatic changes and human activities. The actions of some environmental conditions (acidification, toxic bloom, polluting agents) have been examined on marine organisms at different life phases by laboratory or field experiments. Moreover, great attention has been also focused on the biological properties of marine bioactive molecules with the aim to develop pharmacological applications.

Research Interest: Nitric oxide role and signalling<!--[if gte mso 9]><xml> </xml><xml> Normal 0 false false false EN-IN X-NONE X-NONE </xml><xml> </xml> <style> /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-fareast-language:EN-US;} </style> microplastics

<!--[if gte mso 9]><xml> </xml><xml> Normal 0 false false false EN-IN X-NONE X-NONE </xml><xml> </xml> <style> /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-fareast-language:EN-US;} </style> microplastics, response of marine organisms to environmental factors, biotechnological potential of marine organisms

Grants: 

-2018-2019    Flagship Research Project MicroMARE, MICROplastics in the MARine Environment: colonization by microbes and their effect on benthic model organisms. PI.
-2017-2020    Project ABBACO - Restauro Ambientale e Balneabilita’ del SIN Bagnoli-Coroglio, Participant.

PUBLICATIONS

Author of 105 publications on ISI-journals and 7 book chapters.
Google Scholar H-index = 32; Total citations 3319.

MOST RELEVANT PUBBLICATIONS IN PEER REVIEWED JOURNALS

1.    Migliaccio O, Pinsino A, Maffioli E, Smith AM, Agnisola C, Matranga V, Nonnis S, Tedeschi G, Byrne M, Gambi MC, Palumbo A (2019) Living in future ocean acidification, physiological adaptive responses of the immune system of sea urchins resident at a CO2 vent system. Science of The Total Environment 672: 938-950.

2.    Kumar A, AbdElgawad H, Castellano I, Selim S, Beemster GTS, Asard H, Buia MC,  Palumbo A (2018) Effects of ocean acidification on the levels of primary and secondary metabolites in the brown macroalga Sargassum vulgare at different time scales. Science of the Total Environment  643: 946-956.

3.    Brancaccio M, D’Argenio G, Lembo V,  Palumbo A, Castellano I (2018) Antifibrotic Effect of Marine Ovothiol in an In Vivo Model of Liver Fibrosis. Oxidative Medicine and Cellular Longevity, 2018: Article ID 5045734.

4.    Torres-Águila NP, Martí-Solans J, Ferrández-Roldán A, Almazán A, Roncalli V, D’Aniello S, Romano G, Palumbo A, Albalat R, Cañestro C (2018) Diatom bloom-derived biotoxins cause aberrant development and gene expression in the appendicularian chordate Oikopleura dioica. Communications Biology volume 1, Article number: 121.

5.    Castellano I, Di Tomo P, Di Pietro N, Mandatori D, Pipino C, Formoso G, Napolitano A, Palumbo A, Pandolfi A (2018) Anti-inflammatory activity of marine ovothiol A in an in vitro model of endothelial dysfunction induced by hyperglycemia. Oxidative Medicine and Cellular Longevity, special issue "Therapeutic Potential of Natural Antioxidants". 2018: 2087373.

6.    Castellano I, Migliaccio O, Ferraro G, Maffioli E, Marasco D, Merlino A, Zingone A, Tedeschi G, Palumbo A (2018) Biotic and environmental stress induces nitration and changes in structure and function of the sea urchin major yolk protein toposome. Scientific Reports  8:4610.

7.    Palumbo A, Castellano I, Napolitano A (2018) Ovothiol: a potent natural antioxidant from marine organisms. In Blue Biotechnology. Production and use of marine molecules. Part 2: Marine molecules for disease treatment /prevention and for biological research. La Barre S, Bates SS, Eds., pp. 583-610, Wiley VCH, Weinheim, Germany, 2018.

8.    Annona G, Caccavale F, Pascual-Anaya J, Kuratani S, De Luca P, Palumbo A, D’Aniello S. (2017) Nitric Oxide regulates mouth development in amphioxus. Scientific Reports 7:8432.

9.    Kumar A, Castellano I, Patti FP, Delledonne M, Abdelgawad H, Beemster G, Asard H, Palumbo A, Buia MC (2017) Molecular response of Sargassum vulgare to acidification at volcanic CO2 vents - insights from de novo transcriptomic analysis. Molecular Ecology 26:2276.

10.    Kumar A, AbdElgawad H, Castellano I, Lorenti M, Delledonne M, Beemster GTS, Asard H, Buia MC, Palumbo A (2017) Physiological and Biochemical Analyses Shed Light on the Response of Sargassum vulgare to Ocean Acidification at Different Time Scales. Frontiers Plant Science 8:570.

11.    Trifuoggi M, Pagano G, Guida M, Palumbo A, Siciliano A, Gravina M, Lyons DM, Burić P, Levak M, Thomas PJ, Giarra A, Oral R (2017) Comparative toxicity of seven rare earth elements in sea urchin early life stages. Environmental Science Pollution Research 24:20803.

12.    Oral R, Pagano G, Siciliano A, Gravina M, Palumbo A, Castellano I, Migliaccio O, Thomas P, Guida M, Tommasi F, Trifuoggi M (2017) Heavy rare earth elements affect early life stages in Paracentrotus lividus and Arbacia lixula sea urchins. Environmental Research 154:240.

13.    Migliaccio O, Castellano I, Di Cioccio D, Tedeschi G, Negri A, Cirino P, Romano G, Zingone A, Palumbo A (2016) Subtle reproductive impairment through nitric oxide-mediated mechanisms in sea urchins from an area affected by harmful algal blooms. Scientific Reports 6:26086.

14.    Pagano G, Guida M, Siciliano A, Oral R, Koçbaşc F, Palumbo A, Castellano I, Migliaccio O, Thomas PJ, Trifuoggi M (2016) Comparative Toxicities of Selected Rare Earth Elements: Sea Urchin Embryogenesis and Fertilization Damage with Redox and Cytogenetic Effects.  Environmental Research 147:453.

15.    Castellano I, Migliaccio O, D’Aniello S, Merlino A, Napolitano A, Palumbo A (2016) Shedding light on ovothiol biosynthesis in marine metazoans. Scientific Reports 6:21506.

16.    Migliaccio O, Castellano I, Cirino P, Romano G, Palumbo A (2015) Maternal Exposure to Cadmium and Manganese Impairs Reproduction and Progeny Fitness in the Sea Urchin Paracentrotus lividus. PLoS One 10:e0131815.

17.    Castellano I, Ercolesi E, Romano G, Ianora A, Palumbo A (2015) The diatom-derived aldehyde decadienal affects life cycle transition in the ascidian Ciona intestinalis through nitric oxide/ERK signaling. Open Biology 5:140182.

18.    Migliaccio O, Castellano I, Romano G, Palumbo A (2014) Stress response to cadmium and manganese in Paracentrotus lividus developing embryos is mediated by nitric oxide. Aquatic Toxicology 156:125.

19.    Gallina AA, Brunet C, Palumbo A, Casotti R (2014) The Effect of Polyunsaturated Aldehydes on Skeletonema marinoi (Bacillariophyceae): The involvement of reactive oxygen species and nitric oxide. Marine Drugs 12:4165.

20.    Marrone V, Piscopo M, Romano G, Ianora A, Palumbo A, Costantini M (2012) Defensome against toxic diatom aldehydes in the sea urchin Paracentrotus lividus. PLoS One 7:e31750.

21.    Romano G, Costantini M, Buttino I, Ianora A, Palumbo A (2011) Nitric Oxide Mediates the Stress Response Induced by Diatom Aldehydes in the Sea Urchin Paracentrotus lividus. PLoS One 6:e25980.