Dr. Alessio Metere is a General Surgeon specialising in the surgery of thyroid, parathyroid, and other general surgical procedures. He attended several Italian hospitals and, as Visiting Surgeon, the Columbia University Medical Center of New York. He is also specialized in Clinical Biochemistry and is graduated both, in Medicine and Surgery with honours and in Biological Sciences with honours. He worked as Researcher at the Italian Institute of Health (ISS), focusing his field of research on the role of oxidative stress and innovative biomarkers in thyroid, parathyroid and breast cancers, COPD and Cardiovascular disease. Actually he is engaged as Endocrine Surgeon at Department of Surgical Sciences of "Sapienza" University of Rome and he is responsible for the medical practical activities of Degree Course in Medicine and Surgery of the International Medical School of “Sapienza” University of Rome. Since completing surgical training, Dr. Metere was subsequently engaged in PhD. by “Sapienza” University of Rome, where he is continuing his research on thyroid and breast cancer.

Research Interest: endocrine surgery, bariatric surgery, oxidative stress and innovative biomarkers in thyroid, parathyroid and breast cancers, COPD and Cardiovascular disease.

Grant details:

May 2008 - May 2012        Research Fellow
         Italian National Institute of Health (ISS), Department of Cell Biology and Neurosciences
Research project ISS-NIH: ”Peripheral blood determinants of redox changes in human respiratory disease: biochemical and pathophysiological evaluation”

September 2006 – September 2007        Research Fellow
        Umberto I Hospital, University of Rome “Sapienza”, Department of Cardiovascular, Respiratory and Morphological Sciences
Research project: "Atheromatous plaque progression mechanisms: the role of atorvastatin as modulator of inflammatory processes and cell adhesion"

September 2005 – September 2006        Research Fellow
        Italian National Institute of Health (ISS), Department of Cell Biology and Neurosciences
Research project ISS-NIH: ”Peripheral blood determinants of redox changes in human respiratory disease: biochemical and pathophysiological evaluation”

September 2003 – August 2005        Research Fellow
        Italian National Institute of Health (ISS), Department of Cell Biology and Neurosciences
Research project: “Cell signal transduction mechanisms in Alzheimer's disease and other neurodegenerative pathologies”

Number of Publications List:

1.    METERE A, GIACOMELLI L. Absorption, metabolism and protective role of fruits and vegetables polyphenols against gastric cancer. Eur Rev Med Pharmacol Sci. 2017 Dec;21(24):5850-5858. doi: 10.26355/eurrev_201712_14034.

2.    GIANNOTTI D, CASELLA G, PATRIZI G, DI ROCCO G, CASTAGNETO-GISSEY L, METERE A., BERNIERI MG, VESTRI AR, REDLER A. Spider surgical system versus multiport laparoscopic surgery: performance comparison on a surgical simulator. BMC Surg. 2015 May 3;15:54. doi: 10.1186/s12893-015-0038-9.

3.    SPINELLI FR, DI FRANCO M, METERE A., CONTI F, IANNUCCELLI C, AGATI L, VALESINI G. Decrease of Asymmetric Dimethyl Arginine After Anti-TNF Therapy in Patients with Rheumatoid Arthritis. Drug Dev Res. 2014 Nov;75 Suppl 1:S67-9. doi: 10.1002/ddr.21200.

4.    GUARINO S, DI COSIMO C, CHIESA C, METERE A., DI BELLA V, FILIPPINI A, GIACOMELLI L. (2014). Perioperative care in elderly patients undergoing thyroid surgery. Int J Surg. 2014 Aug 23. pii: S1743-9191(14)00859-0. doi: 10.1016/j.ijsu.2014.08.375.

5.    SPINELLI FR, METERE A., BARBATI C, PIERDOMINICI M, IANNUCCELLI C, LUCCHINO B, CICIARELLO F, AGATI L, VALESINI G, DI FRANCO M. (2013). Effect of Therapeutic Inhibition of TNF on Circulating Endothelial Progenitor Cells in Patients with Rheumatoid Arthritis. Mediators Inflamm. 2013;2013:537539. doi: 10.1155/2013/537539.

6.    CANTISANI V, LODISE P, DI COSIMO C, METERE A., CHIESA C, MANCUSO E, DI SEGNI M, FIORAVANTI C, DI ROCCO G, BERNIERI MG, RICCI P, FIERRO G, GIACOMELLI L, ORSOGNA N, REDLER A. (2013). Metastatic signet ring cell carcinoma presenting as a thyroid diffuse involvement: report of a case studied with Q-elastographic and acoustic radiation force impulse imaging features. Tumori. 2013 May-Jun;99(3):84e-7e. doi: 10.1700/1334.14810.

7.    METERE A., IORIO E, SCORZA G, CAMERINI S, CASELLA M, CRESCENZI M, MINETTI M, PIETRAFORTE D. Carbon Monoxide Signaling in Human Red Blood Cells: Evidence for Pentose Phosphate Pathway Activation and Protein Deglutathionylation. Antioxid Redox Signal. 2013 Aug 2.

8.    DI FRANCO M, SPINELLI FR, METERE A., GERARDI MC, CONTI V, BOCCALINI F, IANNUCCELLI C, CICIARELLO F, AGATI L, VALESINI G. (2013). Serum levels of asymmetric dimethylarginine and apelin as potential markers of vascular endothelial dysfunction in early rheumatoid arthritis. Mediators Inflamm. 2012;2012:347268. doi: 10.1155/2012/347268.

9.    DI COSIMO C., METERE A., CHIESA C., DI ROCCO G., TRULLI F., PACIARONI A., BATTAGLIA S., REDLER A., FIERRO G., GIACOMELLI L. (2012). Mediastinal Parathyroid Adenoma: a case report. Eur Rev Med Pharmacol Sci. 2012 ; 16(6): 845-847.

10.    METERE A., CHIESA C., DI COSIMO C.,  FIERRO G., GIACOMELLI  L., PIETRAFORTE D. (2012). A novel approach to study oxidative stress in thyroid disease: a preliminary study. Eur Rev Med Pharmacol Sci. 2012 ; 16(5):646-652.

11.    METERE A., DI COSIMO C., CHIESA C., ESPOSITO A., GIACOMELLI  L., REDLER A. (2012). An unusual subcutaneous breast cancer metastasis in a 86-year-old woman. Eur Rev Med Pharmacol Sci. 2012 ; 16(4):562-564.

12.    STRAFACE E., MARCHESI A., GAMBARDELLA L., METERE A., TARISSI DE JACOBIS I., VIORA M., GIORDANI L., VILLANI A., DEL PRINCIPE D., MALORNI W AND PIETRAFORTE D. (2012). Does oxidative stress play a critical role in cardiovascular complications of Kawasaki disease? Antioxid Redox Signal. 2012 June 25.

13.    STRAFACE E., GAMBARDELLA L., CANALI E., METERE A., GABRIELLI N., ARCIERI R., MATTATELLI A., LISTA P., AGATI L., MALORNI W. (2010). P-Selectin as a new gender associated biomarker in patients with metabolic syndrome. Int J Cardiol. 2010 Dec 3;145(3):570-1.

14.    STRAFACE E., GAMBARDELLA L., METERE A., MARCHESI A., PALUMBO G., CORTIS E., VILLANI A., PIETRAFORTE D., VIORA M., MALORNI W., DEL PRINCIPE D. (2009). Oxidative stress and defective platelet apoptosis in naïve patients with Kawasaki disease.  Biochem Biophys Res Commun. 2010 Feb 12;392(3):426-30.                                                                       

15.    METERE A., IORIO E., PIETRAFORTE D., PODO F. & MINETTI  M. (2008). Peroxynitrite signaling in human erythrocytes: synergistic role of Hemoglobin oxidation and band 3 tyrosine phosphorylation. Archives of Biochemistry and Biophysics. 2009 Apr 15;484(2):173-82. Review

16.    MINETTI M.,  PIETRAFORTE D., STRAFACE E., METERE A.,  MATARRESE P. & MALORNI W. (2008). Red blood cells as a model to differentiate between direct and indirect oxidation pathways of peroxynitrite. Methods in Enzymology. 2008 vol. 440:253-72.  Review

17.    MALLOZZI C., MARTIRE A., DOMENICI M.R., METERE A., POPOLI P. & DI STASI A.M.M. (2007). L-NAME reverses quinolinic acid-induced toxicity in rat corticostriatal slices: involvement of src family kinases. J Neurosci Res. 2007 Sep; 85(12):2770-7.                            

18.    PIETRAFORTE D, MATARRESE P., STRAFACE E., GAMBARDELLA L., METERE A., SCORZA G., LETO T.L., MALORNI W. & MINETTI M. (2007). Two different pathways are involved in peroxynitrite-induced senescence and apoptosis of human erythrocytes.  Free Radic. Biol. Med. 2007 Jan; 42:202-214.

19.    PIETRAFORTE D., CASTELLI  M., METERE A., SCORZA G., SAMOGGIA P., MENDITTO A. & MINETTI M. (2006). Salivary uric acid at the acidic pH of the stomach is the principal defense against nitrite-derived reactive species: Sparing effects of chlorogenic acid and serum albumin. Free Radic. Biol. Med. 2006 Dec; 41:1753–1763.                                                     

20.    LUCANTONI G., PIETRAFORTE D., MATARRESE P., GAMBARDELLA L., METERE A., PAONE G., BIANCHI E.L. & STRAFACE E. (2006). The red blood cell as bio-sensor for monitoring oxidative imbalance in chronic obstructive pulmonary disease: an ex vivo and in vitro study. Antioxid Redox Signal. 2006 Jul-Aug; 8(7-8):1171-82.                                   

21.    METERE A., MALLOZZI C., MINETTI M., DOMENICI M.R., POPOLI P. & Di STASI A.M.M. (2006). Quinolinic acid modulates the activity of src family  kinases in rat striatum: in vivo and in vitro studies. Journ. Neurochem. 2006 Jun; 97:1327-1336.                                        

22.    NEGRI L., LATTANZI R., GIANNINI E., METERE A., COLUCCI M., BARRA D., KREIL G. & MELCHIORRI P. (2002). Nociceptive sensitization by the secretory protein Bv8. Br. J. Pharmacol. 2002 Dec; 137(8):1147-54.