Aditya Yashwant Sarode
I am a Postdoctoral Research Scientist
at the Columbia University Irving Medical Center where I am understanding the
mechanism of AICDA, a DNA mutator with paramount importance in antibody
diversity in on target activity using human Bcells. I am studying this by
targeted degradation of essential proteins using a state of art technology
called Degron system which are generated using knockin and single cell cloning.
These targets were identified from mass spec and mutations seen in DHL and
DLBCL a form of Bcell lymphoma.
During my Ph.D I delineated interaction
between CD40L- CD40 during a macrophages T cell interaction using residue
specific functions on CD40L which are reported in hyper IgM syndrome. While
studying this I also generated avirulent strains of Leishmania parasites which
we testes as a vaccine strain in different knockout mice and studied the immune
response elicited by this vaccine. I also developed a DNA vaccine against one of
the target proteins in the Leishmania and testes it. During my master's in
Virology from the National Institute of Virology, Pune I study different
classes of virus and their pathogenesis. In particular, I studied the role of
host kinases in the pathogenesis of the Japanese Encephalitis virus for my
master's dissertation. I have a deep understanding of Immunology, APC-Tcell
interaction, host-pathogen interactions, RNA biology, Bcell biology and
vaccines. My area of interest is immunology, tumor immunology, macrophages,
Bcells, host-pathogen interactions, virology, RNA biology, and cancer biology.
Research Interest: Lymphoma, Bcell biology,
receptor-ligand interaction, host-pathogen-interaction, macrophages and tumor
immunity
Indexing/Archiving
Editor-in-Chief
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Jose Manuel Ramia-Angel
Guadalajara University Hospital , Spain Journal of Surgery and Surgical Research |
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Richard Hogston
Leeds Beckett University, UK Archives of Community Medicine and Public Health |
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EXBRAYAT Jean-Marie
Catholic University of Lyon, France Annals of Cytology and Pathology |
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Wei Min HUANG
Nanyang Technological University, Singapore Archive of Biomedical Science and Engineering |
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Emmanouil Magiorkinis
Metaxas Memorial Anticancer Hospital , Greece Annals of Bone Marrow Research |
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Hongxing Dai
Beijing University of Technology , PR China Journal of Civil Engineering and Environmental Sciences |
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Peter Lloyd Nara
Private Compnay- Biological Mimetics, Inc., USA Annals of Antivirals and Antiretrovirals |
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Erich Cosmi
University of Padua, Italy Journal of Gynecological Research and Obstetrics |
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Prof. Pierre Guertin
Laval University, Canada International Journal of Pharmaceutical Sciences and Developmental Research |
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Stavros Dimopoulos
University of Athens, Greece Journal of Novel Physiotherapy and Physical Rehabilitation |
NIH Funded Articles
Research Articles
February 25, 2016Acute Management of Renal Colic and Compliance with National Standards: Closure of the Audit Loop
February 01, 2016Respiratory system pathologies in patients who underwent total laryngectomy due to larynx cancer
May 02, 2020
